Helena de Puig Guixe
Ph.D. Candidate
Department of Mechanical Engineering
Massachusetts Institute of Technology
77 Massachusetts Ave.
MIT Room E25-406
Cambridge, MA, 02139

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MIT Department of Mechanical Engineering, 2013-Present

Ph.D. Candidate in Mechanical Engineering. Gehrke Lab.

Dissertation: Increasing the sensitivity of lateral flow devices for rapid, multiplexed disease diagnostics

Graduate Certificate in Technology and Policy (minor), MIT Engineering Systems Division

MIT Department of Mechanical Engineering, 2013

MS in Mechanical Engineering. Hamad-Schifferli Lab.

Dissertation: “Control of blood clotting using gold nanorods”

Institut Quimic de Sarria (IQS), Universitat Ramon Llull, Spain 2011

Industrial Engineer

Master IQS in Research in Industrial Engineering 2011

Fellowships and Awards:

Rafael del Pino Fellowship for graduate students 2014-Present

-Awarded to 12 students in Spain

La Caixa Fellowship to fulfill graduate studies in the US. 2011- 2013

- Awarded to 40 students in Spain, full tuition and stipend.

MIT GSC conference travel grant 2013

Pare Salvador Gil Award from IQS for research excellence 2012

European Materials Research Society, Bionano@Nice travel award 2011

MOBINT fellowship from the Catalan Government 2010

Experience and employment:

Graduate Research at MIT Cambridge, MA June 2013-Present

Development of low-cost lab-on-a-chip devices for the diagnosis of tropical diseases. Synthesis and functionalization of gold nanoparticles for the detection of disease. Assembly and testing of point of care diagnostic devices.

Gehrke Lab, Institute for Medical Engineering and Science, MIT-IMES; and Department of Microbiology and Immunobiology, Harvard University.

Graduate Research at MIT Cambridge, MA January-June 2013

Synthesis of semiconductor nanowires by metal-organic chemical vapor deposition. Electron microscopy and characterization of semiconductors.

Gradečak Lab. Department of Materials Science and Engineering, MIT

Graduate Research at MIT Cambridge, MA 2010-2012

Control blood coagulation by laser excitation of nanoparticle-DNA conjugates. Characterization of protein coronas surrounding nanoparticles. Quantification of the interactions at the nanoscale.

Hamad-Schifferli Lab, Departments of Mechanical Engineering and Biological Engineering, MIT

Undergraduate Research at IQS Barcelona, Spain 2009

Designed a spray drying machine to produce hydroxyapatite powder for three dimensional printing of knee prostheses.

Borros Lab, GEMAT, IQS, URL

Internship at Iberpotash Barcelona, Spain Summer, 2008

Monitored the flow of the potash in the factory and designed a program to detect errors in the production process. Identified key modifications to improve the yield of the factory.


6.   H. de Puig, J. Tam, C. Yen, L. Gehrke, K. Hamad-Schifferli, “The Extinction Coefficient of Gold Nanostars.”, 2015, Journal of Physical Chemistry C, 110, 17408-17415

5.   C. Yen, H. de Puig, J. Tam, J. Gómez-Márquez, I. Bosch, K. Hamad-Schifferli, L. Gehrke, “Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue fever, Yellow fever and Ebola Viruses.” 2015, Lab on a Chip, 15, 1638-1641.

       The top-scoring Altmetrics article (#1 of of 1410 articles) published in Lab on a Chip January-March 2015.

       Covered by over 60 press articles.

4.   S. Tibbits, L. Kara'in, J. Schaeffer, H. de Puig, J. Gomez-Marquez, A. Young, "DNA disPLAY: Programmable Bioactive Materials Using CNC Patterning", 2014, Architectural Design, 84 (4).

3.   A. Cifuentes Rius*, H. de Puig*, J. C.-Y. Kah, S. Borros, K. Hamad-Schifferli, “Optimizing the Properties of the Protein Corona Surrounding Nanoparticles for Tuning Payload Release”, 2013, ACS Nano,7(11).

*equal first authors

2.   H. de Puig, A. Cifuentes Rius, D. C. Flemister, S.H. Baxamusa, K. Hamad-Schifferli, “Selective Light-Triggered Release of DNA from Gold Nanorods Switches Blood Clotting On and Off”, 2013, PLoS ONE 8(7) : E68511.

Covered by ~40 press articles.

1.   H. de Puig*, S. Federici*, S.H. Baxamusa, P. Bergese, K. Hamad-Schifferli, “Quantifying the nanomachinery of the nanoparticle-biomolecule interface”, Small, 2011, 7 (17), 2477–2484.

*equal first authors


K. Hamad-Schifferli, H. de Puig, S.H. Baxamusa. Reversible control of blood clotting using light. U.S. Application No.: 61/973290.

Conference presentations:

13. American Chemical Society (ACS) Boston National Meeting, 2015. Oral Communication. “Detection of biological threats using gold nanoparticles in lateral flow immunoassays: Dengue hemorrhagic fever

12. American Chemical Society (ACS) Boston National Meeting, 2015. Oral Communication. “Loading and releasing payloads from protein coronas surrounding gold nanoparticles”

11. Materials Research Society (MRS) Fall Boston, 2014. Oral Communication. “Engineering the protein corona surrounding nanoparticles for biomedical applications"

10. Materials Research Society (MRS) Fall Boston, 2014. Oral Communication. “Engineering gold nanoparticles for lateral flow devices to detect tropical diseases"

9. MIT-SUTD International Design Center, 2014 Poster. “Engineered nanoparticles for the diagnosis of dengue in lateral flow immunoassays

8. MIT Materials Day, 2014. Poster. “Engineering the protein corona surrounding nanoparticles for biomedical applications"

7. MIT-SUTD International Design Center, 2013 Poster. “Increasing the sensitivity of lateral flow devices for rapid diagnosis of tropical diseases”

6. Materials Research Society (MRS) Spring San Francisco, 2013. Oral Communication. “Gold nanorod optical switch for controlling blood clotting"

5. MIT Materials Day, 2012. Poster. “Triggered release from gold nanorods"

4. Materials Research Society (MRS) Fall 2011 meeting. Poster. “Selective triggered release from gold nanorods"

3. European Materials Research Society (E-MRS), Nice 2011 Spring meeting. Oral Communication. “Control of blood clotting using gold nanorods"

2. American Chemical Society (ACS), Boston 2010 National meeting. Poster. “Studying the interactions of gold nanoparticles with proteins"

1. MIT Materials Day, 2010.Poster. “Studying the interactions of gold nanorod-aptamer conjugates with thrombin”


MIT. M.S. in Mechanical Engineering. Dissertation: “Control of blood clotting using gold nanorods”

IQS, URL. Master IQS in Industrial Engineering. Dissertation: "Nanomachinery at the nanoparticle-biomolecule interface"

IQS, URL. Industrial Engineering Thesis. Dissertation: Control of blood clotting using gold nanoparticles"


Spanish and Catalan– Native languages.

English – Fluent.



Spain@MIT committee Member, 2012-2014

President and committee member of the Spanish Reining Horse Association, 2008-2010


Reining Amateur Reserve Champion of Spain (CTO* ESP, CRN*). 2009


Nursing home in Kretinga, Lithuania. Montblanc foundation, 2003

Montalegre Association, Raval, Barcelona, Spain, 2002


Official Music studies. Instruments: Piano and Clarinet. Member of musical groups and bands as a pianist and clarinetist.


Enginyers Industrials de Catalunya (EIC)

American Chemical Society (ACS)

Materials Research Society (MRS)